Self-Reported Fatigue and Its Cross-Sectional Associations with Physical Function throughout Adulthood: The INSPIRE-T Cohort
Résumé
405Received March 18, 2024
Accepted for publication May 7, 2024
Original Research
Abstract
BACKGROUND: Fatigue negatively impacts health outcomes but its
association with physical function across the adulthood remains unclear.
OBJECTIVES: This study described self-reported fatigue levels across
age and sex categories, investigated the associations between fatigue
and physical functions, and examined whether age and sex moderated
their associations.
DESIGN: Cross-sectional design.
SETTING: Community.
PARTICIPANTS: Nine hundred sixteen participants aged 20-100 years
in the observational INSPIRE-T cohort study.
MEASUREMENTS: Participants were classified into four age
categories. Fatigue was assessed using the Patient-Reported Outcomes
Measurement Information System (Short Form v1.0 – Fatigue 8a) and
physical function was assessed by handgrip strength (HGS, Kg), usual
gait speed (UGS, m/s), both 5-repetition (5CR, s) and 30-sec chair
rise tests (30sCR, times), isokinetic knee extension strength (IKES,
N m), and maximum oxygen consumption (V̇O2 max, ml/kg/min).
Multiple linear regressions were performed to examine the associations
between fatigue and the physical function outcomes (all square-root-
transformed). Interactions of fatigue with age and sex were considered.
RESULTS: Fatigue levels were the highest in people 75+ years. Women
had a higher fatigue level than men. Fatigue was significantly associated
with decreasing performance in UGS, HGS, 5CR, and 30sCR but not
in IKES and V̇O2 max. Interaction analyses revealed that fatigue was
associated with reduced UGS as people age (Fatigue × age: B = -0.002,
95% confidence interval = -0.003, -0.001). Sex did not moderate the
association between fatigue and physical function.
CONCLUSIONS: Our study indicated that fatigue was negatively
associated with several components of physical function. Although sex
did not moderate the relationship between fatigue and physical function,
the association between fatigue and low UGS was more pronounced
with increasing age.
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